Dihydromyricetin (DHM) is one of the most-studied flavonoids for alcohol metabolism support, liver function support, and antioxidant pathways. Joyrise didn't invent DHM — we engineered it for better absorption.
100×
More bioavailable than standard DHM
30 min
Fast-acting onset
12+
Peer-reviewed studies cited
US11871770B1
U.S. patent for our MBT delivery system
Joyrise's science page summarizes peer-reviewed research on DHM (dihydromyricetin) — the flavonoid sourced from Vine Tea that has been studied for supporting alcohol metabolism, acetaldehyde metabolism pathways, GABA-A receptor balance, and antioxidant (Nrf2) pathways. This research describes a dietary ingredient, not a drug.
Joyrise's patented MBT delivery system (US11871770B1) is engineered for up to 100× better DHM absorption than raw DHM. For broader background, see the DHM supplement hub and how alcohol metabolism works, what acetaldehyde is, and the DHM hangover relief guide.
These statements have not been evaluated by the Food and Drug Administration. Joyrise is not intended to diagnose, treat, cure, or prevent any disease. Always drink responsibly.
DHM is a natural flavonoid extracted from the Japanese raisin tree (Hovenia dulcis) and Vine Tea (Ampelopsis grossedentata) — plants used in traditional East Asian medicine for over 1,000 years to support the liver and ease the after-effects of drinking.
In 2012, a UCLA team led by Dr. Jing Liang published the first major modern study of DHM in The Journal of Neuroscience. In that animal research, DHM acted on biological pathways rather than on symptoms alone — the GABA‑A receptor in the brain and liver enzymes involved in alcohol metabolism. It was a preclinical study, so it describes mechanisms in animals, not proven outcomes in people.
Read the UCLA paper
Did you know
Vine Tea contains the highest known concentration of flavonoids on Earth — up to 9.37%.
The hangover isn't one thing — it's the collision of acetaldehyde toxicity, GABA rebound, and oxidative stress. DHM intervenes at all three.
In animal and cell research, DHM has been reported to increase activity of ADH and ALDH, the enzymes that convert alcohol → acetaldehyde → acetate. Acetaldehyde is associated with many after-effects of drinking. How much this preclinical mechanism translates into next-morning outcomes in people has not been established.
Silva et al., 2020
Alcohol artificially boosts GABA, then crashes it — leaving you anxious and wired the next day ("hangxiety"). DHM modulates GABA‑A receptors to dampen that rebound and restore balance.
Shen et al., UCLA, 2012
Preclinical studies report DHM effects on Nrf2 signaling and autophagy pathways involved in cellular antioxidant responses. Human clinical significance has not been established.
Qiu et al., 2017
Pure DHM is poorly water-soluble. Studies estimate that less than 4% of a standard oral DHM dose actually makes it into circulation. That's why most "DHM gummies" and "hangover pills" feel like nothing.
Joyrise solves this with our patented Mitochondrial Biogenesis Technology (MBT) catalyst — a delivery system that increases DHM bioavailability by up to 100×, improving how much of the active molecule is absorbed compared with standard DHM ingredients.
Protected by U.S. Patent US11871770B1
Researchers keep publishing on DHM. Here's what the literature describes the molecule may support — in cell, animal, and human studies.
Preclinical studies report reduced hepatic fat accumulation and lower markers of liver injury after DHM administration.
Animal research suggests DHM may support memory performance and protect neurons under stress conditions.
Studies have examined DHM's role in supporting insulin sensitivity and lipid metabolism in animal models.
DHM has been shown to activate Nrf2 antioxidant defenses and modulate inflammation-related signaling in preclinical work.
These statements describe published research on the DHM molecule and have not been evaluated by the FDA. Joyrise is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.
Concise, plain-language summaries of each area DHM has been studied for. Where evidence is preclinical (cell or animal), we label it. Joyrise is a dietary supplement, not a medicine.
Dihydromyricetin is a flavonoid found in highest known concentrations in Vine Tea — Ampelopsis grossedentata, traditionally consumed across southern China for centuries. Joyrise standardizes DHM extracted from this source so each capsule delivers a consistent dose, batch after batch.
Ingredient detail: the DHM page.
Alcohol is converted to acetaldehyde — a reactive metabolite tied to next-morning symptoms — and then to acetate by the ADH and ALDH enzyme pathways. Published research describes DHM as supporting these acetaldehyde metabolism pathways, helping the body process alcohol more efficiently.
Background: what is acetaldehyde · DHM for hangover relief.
Sleep disruption and rebound effects on GABA-A signaling are part of why mornings after drinking can feel foggy. DHM has been studied for GABA-A modulation in preclinical models — the basis for its structure/function role in supporting cognitive clarity the next morning.
Use as directed: fast hangover relief · capsule format.
Drinking generates reactive oxygen species. Preclinical research (Qiu et al., 2017) describes DHM as activating the Keap-1/Nrf2 pathway — a central antioxidant response — and modulating inflammation-related signaling. These effects support the body's normal oxidative-stress response.
Compare formats: hangover pills · best hangover pills.
Animal studies have examined DHM in the context of exercise-induced oxidative stress and muscle fatigue, with results pointing to antioxidant activity that may support recovery. Evidence is preclinical; human research is ongoing.
Pure DHM is poorly water-soluble, which limits how much reaches circulation from a standard oral dose. Joyrise's patented Mitochondrial Biogenesis Technology (MBT) delivery system was developed to improve DHM bioavailability versus a standard DHM ingredient — see the DHM page for ingredient details and best hangover relief for category context.
Structure/function statements describe a dietary ingredient based on published research. These statements have not been evaluated by the Food and Drug Administration. Joyrise is not intended to diagnose, treat, cure, or prevent any disease. Always drink responsibly.
Don't take our word for it. Read the studies — published in peer-reviewed journals, indexed on PubMed.
Shen, Lindemeyer, Gonzalez, Shao, Spigelman, Olsen, Liang
The landmark UCLA study, conducted in rats. In this preclinical model, DHM reduced measures of alcohol intoxication and withdrawal and lowered alcohol-seeking behavior, apparently by acting on the GABA‑A receptor. Animal findings do not establish the same effects in people.
Read on PubMedSilva, Yu, Moradian, Folk, Spatz, Kim et al.
In mouse and cell models, DHM was associated with faster ethanol metabolism, lower liver fat accumulation, and lower markers of alcohol-related liver injury. These preclinical findings do not establish human outcomes.
Read on PubMedMartínek et al.
Mechanistic review of how DHM is associated with alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) — pathways involved in processing acetaldehyde.
Read on PubMedQiu et al.
In preclinical liver models, DHM influenced Nrf2 antioxidant signaling and autophagy pathways associated with cellular responses to oxidative stress; human outcome evidence remains limited.
Read on PubMedSilva, Yu, Qi, Davies, Liang
In a preclinical study, DHM combined with complementary flavonoids produced stronger measured effects than DHM alone. This does not prove a finished-product benefit in people.
Read on PubMedSpigelman, Olsen, Liang et al.
In an animal model of prenatal alcohol exposure, DHM affected GABA-A-related pathways and measured developmental outcomes. This does not support use in pregnancy or establish human benefit.
Read on PubMedIndependent coverage
Beyond the Hangover Cure: What Social Drinkers Should Know About DHM and Alcohol Wellness — Vents Magazine, published August 15, 2026. Third-party coverage of DHM and alcohol wellness, listed for further reading; it is not an endorsement of Joyrise.
Joyrise is a patented DHM (dihydromyricetin) dietary supplement engineered for absorption. It pairs DHM with a proprietary MBT delivery system (U.S. Patent US11871770B1) to support the body's normal alcohol-metabolism pathways. Joyrise is a dietary supplement — not a medicine — designed for adults 21+ who choose to drink responsibly.
Joyrise is designed for adults 21+ who want structure/function support for normal alcohol metabolism and next-morning clarity around social drinking, travel, weddings, and everyday antioxidant routines. It is not intended for anyone under 21, pregnant or nursing, on prescription medication, or with a liver condition without medical guidance.
Joyrise builds on peer-reviewed DHM research covering ADH/ALDH alcohol-metabolism enzymes, GABA-A modulation, and Nrf2 antioxidant pathways, and pairs it with a patented MBT delivery system engineered to improve DHM absorption over raw DHM. Products ship in vegan capsules, single-serve packets, and recovery powder sticks — third-party tested in GMP-certified U.S. facilities. See the DHM guide, DHM bioavailability page, and the shop for details.
DHM (dihydromyricetin) is a flavonoid studied for supporting the body's normal alcohol-metabolism pathways — specifically the ADH and ALDH enzymes that convert ethanol into acetaldehyde and then into acetate. It is a dietary supplement ingredient, not a drug, and does not remove acetaldehyde or fix hangovers.
Raw DHM has very low oral bioavailability — most of what you swallow is not absorbed. Without a delivery system, label dose is not the same as the dose that reaches your liver. Joyrise's patented MBT delivery system (U.S. Patent US11871770B1) is designed to improve DHM absorption.
Yes. Much of the foundational mechanistic work is preclinical (cell and animal models). Human clinical evidence on hangover-related outcomes is still emerging and varies in study design and quality. We summarize what the literature says without overstating it.
Acetaldehyde is a reactive intermediate the liver produces when it breaks down ethanol. DHM has been studied for supporting the ADH/ALDH pathways involved in acetaldehyde processing. See our explainer on acetaldehyde for the full pathway.
No. Joyrise is a dietary supplement, not medicine. It does not cure, prevent, or treat hangovers or any disease. It is designed to support normal alcohol metabolism alongside responsible drinking, hydration, food, and sleep.
The most-cited work is Shen et al. (2012) in The Journal of Neuroscience, which described DHM's effects on GABA-A receptors and ethanol response. Additional peer-reviewed studies have examined DHM in the context of ALDH and ADH activity, Nrf2 antioxidant signaling, and liver function support. This is structure/function research on a flavonoid — not disease-treatment evidence.
No. DHM is a dietary supplement ingredient, not an FDA-approved drug. No dietary supplement — DHM or otherwise — is approved to treat, cure, or eliminate alcohol after-effects. Joyrise is manufactured in GMP-certified U.S. facilities and third-party tested for purity and potency.
Joyrise's Mitochondrial Biogenesis Technology (MBT) delivery system for DHM is protected by U.S. Patent US11871770B1. The patent covers the absorption approach engineered to move more DHM into the bloodstream than raw dihydromyricetin, which has bioavailability estimated under 4% in published literature.
Engineered for absorption. Grounded in the published DHM literature — much of it preclinical. Manufactured in the USA in GMP-certified facilities.
Keep reading: DHM, DHM for hangover relief, what is acetaldehyde, hangover pills, best DHM supplement, DHM bioavailability, fast-acting capsules, best hangover pills, hangover relief capsules, relief for travel, and relief for weddings.
DHM has one of the deepest research files in the natural alcohol-support category, but most published work is preclinical (cell culture, rodent models) with a smaller set of human studies. That's normal for supplement ingredients. The honest way to read the literature is that DHM has structure/function support for normal alcohol metabolism, ALDH/ADH activity, GABA-A receptor balance, and antioxidant (Nrf2) defense — not that DHM cures or prevents anything.
Peer-reviewed work has examined DHM in the context of ethanol metabolism kinetics, acetaldehyde processing via ALDH, Nrf2 antioxidant signaling, GABA-A receptor modulation, and liver oxidative stress. See how alcohol metabolism works, what acetaldehyde is, and why bioavailability gates any DHM study.
U.S. Patent US11871770B1 covers Joyrise's Mitochondrial Biogenesis Technology (MBT) delivery system for DHM. Absorption is the gating variable for any DHM study — with raw dihydromyricetin under 4% bioavailable in published estimates, a study "using DHM" is really studying whatever fraction reached the bloodstream. A delivery system is the difference between label milligrams and effective milligrams.
Joyrise leads with DHM as the primary active, uses a patented absorption system, is caffeine-free, vegan, third-party tested, and manufactured in GMP-certified U.S. facilities. That's the applied version of the research: the most-studied ingredient in the most absorbable form the current science supports. See the DHM guide and DHM hangover relief support.
Joyrise is a patented DHM alcohol-support product designed to support alcohol metabolism and next-morning clarity for adults 21+. It is available in three formats — fast-acting capsules, single-serve capsule packets, and recovery powder stick packs. The formula is caffeine-free, vegan, and third-party tested, uses a patented bioavailable DHM delivery system (U.S. Patent US11871770B1), and is backed by a 30-day money-back guarantee.
These statements have not been evaluated by the Food and Drug Administration. Joyrise is a dietary supplement for adults 21+ and is not intended to diagnose, treat, cure, or prevent any disease. Always drink responsibly.