Why Most DHM Supplements Don’t Work — And How Joyrise Fixed It

Why Most DHM Supplements Don’t Work — And How Joyrise Fixed It

You may have heard about dihydromyricetin (DHM), the natural flavonoid studied for easing hangovers, protecting the liver, and calming “hangxiety.” But here’s what most brands won’t tell you:

DHM on its own isn’t very bioavailable. In plain English, your body barely absorbs it — which is why most DHM capsules on the market fail to deliver meaningful results.

Joyrise® was created to solve that exact problem — and the science behind it is now protected by a U.S. patent (US11871770B1).

The Bioavailability Problem

  • Poor solubility: DHM doesn’t dissolve well in water. In animal studies, less than 5% of a dose reached the bloodstream (Xenobiotica, 2017).
  • Rapid breakdown: The small amount absorbed is quickly metabolized.
  • Transport barriers: Proteins in the gut actively pump DHM back out before it can circulate (Drug Metabolism and Disposition, 2018).

This means swallowing huge milligram doses isn’t the answer — most of it is wasted without a delivery system.

What the Research Shows About Improving Absorption

Scientists have tested several advanced ways to make DHM more effective:

The lesson is clear: delivery science matters as much as the ingredient itself.

How Joyrise Solves the Problem (Backed by Patent US11871770B1)

Instead of relying on theories that rarely make it to market, Joyrise created — and patented — its own delivery system. Our approach:

  • Patented blend of sweeteners and carriers that makes DHM dissolve and stay stable.
  • Improved absorption so more DHM actually reaches the bloodstream.
  • Fast-acting relief — benefits felt in as little as 30 minutes.

This patented system (U.S. Patent No. 11871770B1) is unique to Joyrise, meaning you can’t get it anywhere else.

Bottom Line

DHM is powerful on paper — but nearly useless unless your body can absorb it. That’s why most products fail.

Joyrise cracked the code with our patented delivery system, making DHM highly bioavailable, fast-acting, and effective.

When you choose Joyrise, you’re choosing the only DHM supplement built on real patented science — not just marketing claims.

References

  1. Xenobiotica (2017) – DHM’s low oral bioavailability
  2. Drug Metabolism and Disposition (2018) – Efflux transport limiting DHM absorption
  3. Molecules (2019) – Cyclodextrin inclusion complexes improve solubility
  4. International Journal of Pharmaceutics (2020) – Cocrystals increasing DHM bioavailability
  5. Pharmaceutics (2022) – Nanocarriers and micelles improving flavonoid delivery
  6. US Patent US11871770B1 – Joyrise patented sweetener additive delivery system
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