🧠 Could a Hangover Molecule Protect Your Brain From Alzheimer’s?

Dihydromyricetin (DHM) is best known as the natural extract that helps you recover faster after drinking. But in the last decade, scientists have discovered something remarkable — DHM may also help defend the brain from age-related decline and even Alzheimer’s-type changes.

While research is still early, the results from laboratory and animal models are promising. Here’s what science is beginning to reveal about DHM’s potential to protect memory, reduce neuroinflammation, and support long-term brain health — and why Joyrise^® delivers this compound in the form your body can actually use.

Alcohol, Aging, and Brain Damage: A Shared Pathway

Both chronic drinking and neurodegenerative diseases like Alzheimer’s share a key culprit — oxidative stress and neuroinflammation. These processes damage neurons, impair learning, and accelerate aging of brain tissue (Front Aging Neurosci. 2022).

DHM, extracted from Ampelopsis grossedentata (vine tea), has powerful antioxidant and anti-inflammatory effects. Scientists began studying it for hangover recovery — then noticed it also seemed to protect neurons from alcohol-related toxicity.

DHM and Alzheimer’s: What the Studies Show

• Prevents memory decline: In an Alzheimer’s mouse model, DHM improved learning and memory while reducing amyloid-beta plaque formation and tau phosphorylation (Mol Neurobiol. 2018).
• Regulates key brain pathways: DHM activates AMPK/SIRT1 — enzymes that control mitochondrial health and neuronal longevity (Aging Cell. 2019).
• Reduces inflammation and microglial overactivity: In Alzheimer’s-like models, DHM dampened excessive immune cell activity in the brain, a known driver of neuronal death.

These findings suggest DHM doesn’t just counter the short-term effects of alcohol — it may also support long-term resilience of the brain.

Why Most DHM Supplements Fall Short

The challenge? DHM is poorly absorbed. In its natural form, less than 5% reaches the bloodstream (Xenobiotica, 2017), meaning that most capsules on the market never deliver a meaningful dose to the brain.

How Joyrise Makes It Work

Joyrise’s patented delivery system (U.S. Patent No. 11871770B1) uses natural carriers and solubilizers that dramatically increase DHM’s bioavailability. That means more of the molecule actually reaches circulation — where it can exert its full neuroprotective potential.

By improving absorption, Joyrise transforms DHM from a theoretical brain aid into a practical, fast-acting supplement that supports cognition, focus, and recovery in the same formula.

The Takeaway

While human clinical trials are still ongoing, early research shows DHM supports neuronal health, balances oxidative stress, and promotes pathways linked to longevity. Choosing a bioavailable, patented formulation like Joyrise ensures you’re not just following the science — you’re experiencing it.

References

1. Molecular Neurobiology (2018) – DHM reduced amyloid-beta and improved cognition in Alzheimer’s models.
2. Aging Cell (2019) – DHM activated AMPK/SIRT1, supporting mitochondrial health.
3. Frontiers in Aging Neuroscience (2022) – Review: oxidative stress and neuroinflammation in aging.
4. Xenobiotica (2017) – DHM’s low oral bioavailability.